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In Chemical physics letters

Humans around the globe have been severely affected by SARS-CoV-2 and no treatment has yet been authorized for the treatment of this severe condition brought by COVID-19. Here, an in silico research was executed to elucidate the inhibitory potential of selected thiazolides derivatives against SARS-CoV-2 Protease (Mpro) and Methyltransferase (MTase). Based on the analysis; 4 compounds were discovered to have efficacious and remarkable results against the proteins of the interest. Primarily, results obtained through this study not only allude these compounds as potential inhibitors but also pave the way for in vivo and in vitro validation of these compounds.

Rasool Nouman, Yasmin Farkhanda, Sahai Shalini, Hussain Waqar, Inam Hadiqa, Arshad Arooj

2021-Mar-06

COVID-19, MTase, Mpro, SARS-CoV-2, Thiazolide Derivatives