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Radiology Radiology

Current and emerging artificial intelligence applications for pediatric musculoskeletal radiology.

In Pediatric radiology

Artificial intelligence (AI) is playing an ever-increasing role in radiology (more so in the adult world than in pediatrics), to the extent that there are unfounded fears it will completely take over the role of the radiologist. In relation to musculoskeletal applications of AI in pediatric radiology, we are far from the time when AI will replace radiologists; even for the commonest application (bone age assessment), AI is more often employed in an AI-assist mode rather than an AI-replace or AI-extend mode. AI for bone age assessment has been in clinical use for more than a decade and is the area in which most research has been conducted. Most other potential indications in children (such as appendicular and vertebral fracture detection) remain largely in the research domain. This article reviews the areas in which AI is most prominent in relation to the pediatric musculoskeletal system, briefly summarizing the current literature and highlighting areas for future research. Pediatric radiologists are encouraged to participate as members of the research teams conducting pediatric radiology artificial intelligence research.

Offiah Amaka C


Artificial intelligence, Bone, Children, Musculoskeletal, Pediatric radiology

General General

High-resolution transcription factor binding sites prediction improved performance and interpretability by deep learning method.

In Briefings in bioinformatics

Transcription factors (TFs) are essential proteins in regulating the spatiotemporal expression of genes. It is crucial to infer the potential transcription factor binding sites (TFBSs) with high resolution to promote biology and realize precision medicine. Recently, deep learning-based models have shown exemplary performance in the prediction of TFBSs at the base-pair level. However, the previous models fail to integrate nucleotide position information and semantic information without noisy responses. Thus, there is still room for improvement. Moreover, both the inner mechanism and prediction results of these models are challenging to interpret. To this end, the Deep Attentive Encoder-Decoder Neural Network (D-AEDNet) is developed to identify the location of TFs-DNA binding sites in DNA sequences. In particular, our model adopts Skip Architecture to leverage the nucleotide position information in the encoder and removes noisy responses in the information fusion process by Attention Gate. Simultaneously, the Transcription Factor Motif Discovery based on Sliding Window (TF-MoDSW), an approach to discover TFs-DNA binding motifs by utilizing the output of neural networks, is proposed to understand the biological meaning of the predicted result. On ChIP-exo datasets, experimental results show that D-AEDNet has better performance than competing methods. Besides, we authenticate that Attention Gate can improve the interpretability of our model by ways of visualization analysis. Furthermore, we confirm that ability of D-AEDNet to learn TFs-DNA binding motifs outperform the state-of-the-art methods and availability of TF-MoDSW to discover biological sequence motifs in TFs-DNA interaction by conducting experiment on ChIP-seq datasets.

Zhang Yongqing, Wang Zixuan, Zeng Yuanqi, Zhou Jiliu, Zou Quan


Attention Gate, interpretability, motif discovery, transcription factor binding sites

General General

A comprehensive transferability evaluation of U-Net and ResU-Net for landslide detection from Sentinel-2 data (case study areas from Taiwan, China, and Japan).

In Scientific reports ; h5-index 158.0

Earthquakes and heavy rainfalls are the two leading causes of landslides around the world. Since they often occur across large areas, landslide detection requires rapid and reliable automatic detection approaches. Currently, deep learning (DL) approaches, especially different convolutional neural network and fully convolutional network (FCN) algorithms, are reliably achieving cutting-edge accuracies in automatic landslide detection. However, these successful applications of various DL approaches have thus far been based on very high resolution satellite images (e.g., GeoEye and WorldView), making it easier to achieve such high detection performances. In this study, we use freely available Sentinel-2 data and ALOS digital elevation model to investigate the application of two well-known FCN algorithms, namely the U-Net and residual U-Net (or so-called ResU-Net), for landslide detection. To our knowledge, this is the first application of FCN for landslide detection only from freely available data. We adapt the algorithms to the specific aim of landslide detection, then train and test with data from three different case study areas located in Western Taitung County (Taiwan), Shuzheng Valley (China), and Eastern Iburi (Japan). We characterize three different window size sample patches to train the algorithms. Our results also contain a comprehensive transferability assessment achieved through different training and testing scenarios in the three case studies. The highest f1-score value of 73.32% was obtained by ResU-Net, trained with a dataset from Japan, and tested on China's holdout testing area using the sample patch size of 64 × 64 pixels.

Ghorbanzadeh Omid, Crivellari Alessandro, Ghamisi Pedram, Shahabi Hejar, Blaschke Thomas


General General

GazeBase, a large-scale, multi-stimulus, longitudinal eye movement dataset.

In Scientific data

This manuscript presents GazeBase, a large-scale longitudinal dataset containing 12,334 monocular eye-movement recordings captured from 322 college-aged participants. Participants completed a battery of seven tasks in two contiguous sessions during each round of recording, including a - (1) fixation task, (2) horizontal saccade task, (3) random oblique saccade task, (4) reading task, (5/6) free viewing of cinematic video task, and (7) gaze-driven gaming task. Nine rounds of recording were conducted over a 37 month period, with participants in each subsequent round recruited exclusively from prior rounds. All data was collected using an EyeLink 1000 eye tracker at a 1,000 Hz sampling rate, with a calibration and validation protocol performed before each task to ensure data quality. Due to its large number of participants and longitudinal nature, GazeBase is well suited for exploring research hypotheses in eye movement biometrics, along with other applications applying machine learning to eye movement signal analysis. Classification labels produced by the instrument's real-time parser are provided for a subset of GazeBase, along with pupil area.

Griffith Henry, Lohr Dillon, Abdulin Evgeny, Komogortsev Oleg


General General

Towards omics-based predictions of planktonic functional composition from environmental data.

In Nature communications ; h5-index 260.0

Marine microbes play a crucial role in climate regulation, biogeochemical cycles, and trophic networks. Unprecedented amounts of data on planktonic communities were recently collected, sparking a need for innovative data-driven methodologies to quantify and predict their ecosystemic functions. We reanalyze 885 marine metagenome-assembled genomes through a network-based approach and detect 233,756 protein functional clusters, from which 15% are functionally unannotated. We investigate all clusters' distributions across the global ocean through machine learning, identifying biogeographical provinces as the best predictors of protein functional clusters' abundance. The abundances of 14,585 clusters are predictable from the environmental context, including 1347 functionally unannotated clusters. We analyze the biogeography of these 14,585 clusters, identifying the Mediterranean Sea as an outlier in terms of protein functional clusters composition. Applicable to any set of sequences, our approach constitutes a step towards quantitative predictions of functional composition from the environmental context.

Faure Emile, Ayata Sakina-Dorothée, Bittner Lucie


Radiology Radiology

Optimal timing of cholecystectomy after necrotising biliary pancreatitis.

In Gut ; h5-index 124.0

OBJECTIVE : Following an episode of acute biliary pancreatitis, cholecystectomy is advised to prevent recurrent biliary events. There is limited evidence regarding the optimal timing and safety of cholecystectomy in patients with necrotising biliary pancreatitis.

DESIGN : A post hoc analysis of a multicentre prospective cohort. Patients with biliary pancreatitis and a CT severity score of three or more were included in 27 Dutch hospitals between 2005 and 2014. Primary outcome was the optimal timing of cholecystectomy in patients with necrotising biliary pancreatitis, defined as: the optimal point in time with the lowest risk of recurrent biliary events and the lowest risk of complications of cholecystectomy. Secondary outcomes were the number of recurrent biliary events, periprocedural complications of cholecystectomy and the protective value of endoscopic sphincterotomy for the recurrence of biliary events.

RESULTS : Overall, 248 patients were included in the analysis. Cholecystectomy was performed in 191 patients (77%) at a median of 103 days (P25-P75: 46-222) after discharge. Infected necrosis after cholecystectomy occurred in four (2%) patients with persistent peripancreatic collections. Before cholecystectomy, 66 patients (27%) developed biliary events. The risk of overall recurrent biliary events prior to cholecystectomy was significantly lower before 10 weeks after discharge (risk ratio 0.49 (95% CI 0.27 to 0.90); p=0.02). The risk of recurrent pancreatitis before cholecystectomy was significantly lower before 8 weeks after discharge (risk ratio 0.14 (95% CI 0.02 to 1.0); p=0.02). The complication rate of cholecystectomy did not decrease over time. Endoscopic sphincterotomy did not reduce the risk of recurrent biliary events (OR 1.40 (95% CI 0.74 to 2.83)).

CONCLUSION : The optimal timing of cholecystectomy after necrotising biliary pancreatitis, in the absence of peripancreatic collections, is within 8 weeks after discharge.

Hallensleben Nora D, Timmerhuis Hester C, Hollemans Robbert A, Pocornie Sabrina, van Grinsven Janneke, van Brunschot Sandra, Bakker Olaf J, van der Sluijs Rogier, Schwartz Matthijs P, van Duijvendijk Peter, Römkens Tessa, Stommel Martijn W J, Verdonk Robert C, Besselink Marc G, Bouwense Stefan A W, Bollen Thomas L, van Santvoort Hjalmar C, Bruno Marco J


acute pancreatitis, cholecystectomy