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General General

Current developments in artificial intelligence from obstetrics and gynecology to urogynecology.

In Frontiers in medicine

In today's medical practice clinicians need to struggle with a huge amount of data to improve the outcomes of the patients. Sometimes one clinician needs to deal with thousands of ultrasound images or hundred papers of laboratory results. To overcome this shortage, computers get in help of human beings and they are educated under the term "artificial intelligence." We were using artificial intelligence in our daily lives (i.e., Google, Netflix, etc.), but applications in medicine are relatively new. In obstetrics and gynecology, artificial intelligence models mostly use ultrasound images for diagnostic purposes but nowadays researchers started to use other medical recordings like non-stress tests or urodynamics study results to develop artificial intelligence applications. Urogynecology is a developing subspecialty of obstetrics and gynecology, and articles about artificial intelligence in urogynecology are limited but in this review, we aimed to increase clinicians' knowledge about this new approach.

Seval Mehmet Murat, Varlı Bulut

2023

artificial intelligence, deep learning, machine learning, pelvic organ prolapse, urinary incontinence, urogynecology

Ophthalmology Ophthalmology

Implementation of deep learning artificial intelligence in vision-threatening disease screenings for an underserved community during COVID-19.

In Journal of telemedicine and telecare ; h5-index 28.0

INTRODUCTION : Age-related macular degeneration, diabetic retinopathy, and glaucoma are vision-threatening diseases that are leading causes of vision loss. Many studies have validated deep learning artificial intelligence for image-based diagnosis of vision-threatening diseases. Our study prospectively investigated deep learning artificial intelligence applications in student-run non-mydriatic screenings for an underserved, primarily Hispanic community during COVID-19.

METHODS : Five supervised student-run community screenings were held in West New York, New Jersey. Participants underwent non-mydriatic 45-degree retinal imaging by medical students. Images were uploaded to a cloud-based deep learning artificial intelligence for vision-threatening disease referral. An on-site tele-ophthalmology grader and remote clinical ophthalmologist graded images, with adjudication by a senior ophthalmologist to establish the gold standard diagnosis, which was used to assess the performance of deep learning artificial intelligence.

RESULTS : A total of 385 eyes from 195 screening participants were included (mean age 52.43  ±  14.5 years, 40.0% female). A total of 48 participants were referred for at least one vision-threatening disease. Deep learning artificial intelligence marked 150/385 (38.9%) eyes as ungradable, compared to 10/385 (2.6%) ungradable as per the human gold standard (p < 0.001). Deep learning artificial intelligence had 63.2% sensitivity, 94.5% specificity, 32.0% positive predictive value, and 98.4% negative predictive value in vision-threatening disease referrals. Deep learning artificial intelligence successfully referred all 4 eyes with multiple vision-threatening diseases. Deep learning artificial intelligence graded images (35.6  ±  13.3 s) faster than the tele-ophthalmology grader (129  ±  41.0) and clinical ophthalmologist (68  ±  21.9, p < 0.001).

DISCUSSION : Deep learning artificial intelligence can increase the efficiency and accessibility of vision-threatening disease screenings, particularly in underserved communities. Deep learning artificial intelligence should be adaptable to different environments. Consideration should be given to how deep learning artificial intelligence can best be utilized in a real-world application, whether in computer-aided or autonomous diagnosis.

Zhu Aretha, Tailor Priya, Verma Rashika, Zhang Isis, Schott Brian, Ye Catherine, Szirth Bernard, Habiel Miriam, Khouri Albert S

2023-Mar-13

COVID-19, Tele-ophthalmology, deep learning artificial intelligence, vision screenings

Public Health Public Health

Exploring the impact of sentiment on multi-dimensional information dissemination using COVID-19 data in China.

In Computers in human behavior ; h5-index 125.0

The outbreak of information epidemic in crisis events, with the channel effect of social media, has brought severe challenges to global public health. Combining information, users and environment, understanding how emotional information spreads on social media plays a vital role in public opinion governance and affective comfort, preventing mass incidents and stabilizing the network order. Therefore, from the perspective of the information ecology and elaboration likelihood model (ELM), this study conducted a comparative analysis based on two large-scale datasets related to COVID-19 to explore the influence mechanism of sentiment on the forwarding volume, spreading depth and network influence of information dissemination. Based on machine learning and social network methods, topics, sentiments, and network variables are extracted from large-scale text data, and the dissemination characteristics and evolution rules of online public opinions in crisis events are further analyzed. The results show that negative sentiment positively affects the volume, depth, and influence compared with positive sentiment. In addition, information characteristics such as richness, authority, and topic influence moderate the relationship between sentiment and information dissemination. Therefore, the research can build a more comprehensive connection between the emotional reaction of network users and information dissemination and analyze the internal characteristics and evolution trend of online public opinion. Then it can help sentiment management and information release strategy when emergencies occur.

Luo Han, Meng Xiao, Zhao Yifei, Cai Meng

2023-Jul

COVID-19, Emotional response, Information authority, Information dissemination, Information richness, Topic influence

General General

Non-Contrastive Unsupervised Learning of Physiological Signals from Video

ArXiv Preprint

Subtle periodic signals such as blood volume pulse and respiration can be extracted from RGB video, enabling remote health monitoring at low cost. Advancements in remote pulse estimation -- or remote photoplethysmography (rPPG) -- are currently driven by deep learning solutions. However, modern approaches are trained and evaluated on benchmark datasets with associated ground truth from contact-PPG sensors. We present the first non-contrastive unsupervised learning framework for signal regression to break free from the constraints of labelled video data. With minimal assumptions of periodicity and finite bandwidth, our approach is capable of discovering the blood volume pulse directly from unlabelled videos. We find that encouraging sparse power spectra within normal physiological bandlimits and variance over batches of power spectra is sufficient for learning visual features of periodic signals. We perform the first experiments utilizing unlabelled video data not specifically created for rPPG to train robust pulse rate estimators. Given the limited inductive biases and impressive empirical results, the approach is theoretically capable of discovering other periodic signals from video, enabling multiple physiological measurements without the need for ground truth signals. Codes to fully reproduce the experiments are made available along with the paper.

Jeremy Speth, Nathan Vance, Patrick Flynn, Adam Czajka

2023-03-14

oncology Oncology

ALA-A2 Is a Novel Anticancer Peptide Inspired by Alpha-Lactalbumin: A Discovery from a Computational Peptide Library, In Silico Anticancer Peptide Screening and In Vitro Experimental Validation.

In Global challenges (Hoboken, NJ)

Anticancer peptides (ACPs) are rising as a new strategy for cancer therapy. However, traditional laboratory screening to find and identify novel ACPs from hundreds to thousands of peptides is costly and time consuming. Here, a sequential procedure is applied to identify candidate ACPs from a computer-generated peptide library inspired by alpha-lactalbumin, a milk protein with known anticancer properties. A total of 2688 distinct peptides, 5-25 amino acids in length, are generated from alpha-lactalbumin. In silico ACP screening using the physicochemical and structural filters and three machine learning models lead to the top candidate peptides ALA-A1 and ALA-A2. In vitro screening against five human cancer cell lines supports ALA-A2 as the positive hit. ALA-A2 selectively kills A549 lung cancer cells in a dose-dependent manner, with no hemolytic side effects, and acts as a cell penetrating peptide without membranolytic effects. Sequential window acquisition of all theorical fragment ions-proteomics and functional validation reveal that ALA-A2 induces autophagy to mediate lung cancer cell death. This approach to identify ALA-A2 is time and cost-effective. Further investigations are warranted to elucidate the exact intracellular targets of ALA-A2. Moreover, these findings support the use of larger computational peptide libraries built upon multiple proteins to further advance ACP research and development.

Lerksuthirat Tassanee, On-Yam Pasinee, Chitphuk Sermsiri, Stitchantrakul Wasana, Newburg David S, Morrow Ardythe L, Hongeng Suradej, Chiangjong Wararat, Chutipongtanate Somchai

2023-Mar

SWATH‐MS, anticancer peptides, cytotoxic screening, drug discovery, lung adenocarcinoma, machine learning, peptide library

Pathology Pathology

Artificial intelligence-based HDX (AI-HDX) prediction reveals fundamental characteristics to protein dynamics: Mechanisms on SARS-CoV-2 immune escape.

In iScience

Three-dimensional structure and dynamics are essential for protein function. Advancements in hydrogen-deuterium exchange (HDX) techniques enable probing protein dynamic information in physiologically relevant conditions. HDX-coupled mass spectrometry (HDX-MS) has been broadly applied in pharmaceutical industries. However, it is challenging to obtain dynamics information at the single amino acid resolution and time consuming to perform the experiments and process the data. Here, we demonstrate the first deep learning model, artificial intelligence-based HDX (AI-HDX), that predicts intrinsic protein dynamics based on the protein sequence. It uncovers the protein structural dynamics by combining deep learning, experimental HDX, sequence alignment, and protein structure prediction. AI-HDX can be broadly applied to drug discovery, protein engineering, and biomedical studies. As a demonstration, we elucidated receptor-binding domain structural dynamics as a potential mechanism of anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody efficacy and immune escape. AI-HDX fundamentally differs from the current AI tools for protein analysis and may transform protein design for various applications.

Yu Jiali, Uzuner Ugur, Long Bin, Wang Zachary, Yuan Joshua S, Dai Susie Y

2023-Apr-21

Immunology, Virology