In Frontiers in neuroscience ; h5-index 72.0

BACKGROUND : White matter myelination is a crucial process of CNS maturation. The purpose of this study was to validate the T1w/T2w mapping technique for brain myelination assessment in infants and young children.

METHODS : Ninety-four patients (0-23 months of age) without structural abnormalities on brain MRI were evaluated by using the T1w/T2w mapping method. The T1w/T2w signal intensity ratio, which reflects white matter integrity and the degree of myelination, was calculated in various brain regions. We performed a Pearson correlation analysis, a LOESS regression analysis, and a 2^nd order polynomial regression analysis to describe the relationships between the regional metrics and the age of the patients (in months).

RESULTS : T1w/T2w ratio values rapidly increased in the first 6-9 months of life and then slowed thereafter. The T1w/T2w mapping technique emphasized the contrast between myelinated and less myelinated structures in all age groups, which resulted in better visualization. There were strong positive correlations between the T1w/T2w ratio values from the majority of white matter ROIs and the subjects' age (R = 0.7-0.9, p < 0.001). Within all of the analyzed regions, there were non-linear relationships between age and T1/T2 ratio values that varied by anatomical and functional location. Regions such as the splenium and the genu of the corpus callosum showed the highest R² values, thus indicating less scattering of data and a better fit to the model.

CONCLUSION : The T1w/T2w mapping technique may enhance our diagnostic ability to assess myelination patterns in the brains of infants and young children.

Filimonova Elena, Amelina Evgenia, Sazonova Aleksandra, Zaitsev Boris, Rzaev Jamil

2023

T1w/T2w mapping, children, infants, magnetic resonance imaging, myelination

In JAMA network open

IMPORTANCE : Artificial intelligence (AI) enables powerful models for establishment of clinical diagnostic and prognostic tools for hip fractures; however the performance and potential impact of these newly developed algorithms are currently unknown.

OBJECTIVE : To evaluate the performance of AI algorithms designed to diagnose hip fractures on radiographs and predict postoperative clinical outcomes following hip fracture surgery relative to current practices.

DATA SOURCES : A systematic review of the literature was performed using the MEDLINE, Embase, and Cochrane Library databases for all articles published from database inception to January 23, 2023. A manual reference search of included articles was also undertaken to identify any additional relevant articles.

STUDY SELECTION : Studies developing machine learning (ML) models for the diagnosis of hip fractures from hip or pelvic radiographs or to predict any postoperative patient outcome following hip fracture surgery were included.

DATA EXTRACTION AND SYNTHESIS : This study followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses and was registered with PROSPERO. Eligible full-text articles were evaluated and relevant data extracted independently using a template data extraction form. For studies that predicted postoperative outcomes, the performance of traditional predictive statistical models, either multivariable logistic or linear regression, was recorded and compared with the performance of the best ML model on the same out-of-sample data set.

MAIN OUTCOMES AND MEASURES : Diagnostic accuracy of AI models was compared with the diagnostic accuracy of expert clinicians using odds ratios (ORs) with 95% CIs. Areas under the curve for postoperative outcome prediction between traditional statistical models (multivariable linear or logistic regression) and ML models were compared.

RESULTS : Of 39 studies that met all criteria and were included in this analysis, 18 (46.2%) used AI models to diagnose hip fractures on plain radiographs and 21 (53.8%) used AI models to predict patient outcomes following hip fracture surgery. A total of 39 598 plain radiographs and 714 939 hip fractures were used for training, validating, and testing ML models specific to diagnosis and postoperative outcome prediction, respectively. Mortality and length of hospital stay were the most predicted outcomes. On pooled data analysis, compared with clinicians, the OR for diagnostic error of ML models was 0.79 (95% CI, 0.48-1.31; P = .36; I2 = 60%) for hip fracture radiographs. For the ML models, the mean (SD) sensitivity was 89.3% (8.5%), specificity was 87.5% (9.9%), and F1 score was 0.90 (0.06). The mean area under the curve for mortality prediction was 0.84 with ML models compared with 0.79 for alternative controls (P = .09).

CONCLUSIONS AND RELEVANCE : The findings of this systematic review and meta-analysis suggest that the potential applications of AI to aid with diagnosis from hip radiographs are promising. The performance of AI in diagnosing hip fractures was comparable with that of expert radiologists and surgeons. However, current implementations of AI for outcome prediction do not seem to provide substantial benefit over traditional multivariable predictive statistics.

Lex Johnathan R, Di Michele Joseph, Koucheki Robert, Pincus Daniel, Whyne Cari, Ravi Bheeshma

2023-Mar-01

In JAMA network open

IMPORTANCE : Firearm homicides are a major public health concern; lack of timely mortality data presents considerable challenges to effective response. Near real-time data sources offer potential for more timely estimation of firearm homicides.

OBJECTIVE : To estimate near real-time burden of weekly and annual firearm homicides in the US.

DESIGN, SETTING, AND PARTICIPANTS : In this prognostic study, anonymous, longitudinal time series data were obtained from multiple data sources, including Google and YouTube search trends related to firearms (2014-2019), emergency department visits for firearm injuries (National Syndromic Surveillance Program, 2014-2019), emergency medical service activations for firearm-related injuries (biospatial, 2014-2019), and National Domestic Violence Hotline contacts flagged with the keyword firearm (2016-2019). Data analysis was performed from September 2021 to September 2022.

MAIN OUTCOMES AND MEASURES : Weekly estimates of US firearm homicides were calculated using a 2-phase pipeline, first fitting optimal machine learning models for each data stream and then combining the best individual models into a stacked ensemble model. Model accuracy was assessed by comparing predictions of firearm homicides in 2019 to actual firearm homicides identified by National Vital Statistics System death certificates. Results were also compared with a SARIMA (seasonal autoregressive integrated moving average) model, a common method to forecast injury mortality.

RESULTS : Both individual and ensemble models yielded highly accurate estimates of firearm homicides. Individual models' mean error for weekly estimates of firearm homicides (root mean square error) varied from 24.95 for emergency department visits to 31.29 for SARIMA forecasting. Ensemble models combining data sources had lower weekly mean error and higher annual accuracy than individual data sources: the all-source ensemble model had a weekly root mean square error of 24.46 deaths and full-year accuracy of 99.74%, predicting the total number of firearm homicides in 2019 within 38 deaths for the entire year (compared with 95.48% accuracy and 652 deaths for the SARIMA model). The model decreased the time lag of reporting weekly firearm homicides from 7 to 8 months to approximately 6 weeks.

CONCLUSIONS AND RELEVANCE : In this prognostic study of diverse secondary data on machine learning, ensemble modeling produced accurate near real-time estimates of weekly and annual firearm homicides and substantially decreased data source time lags. Ensemble model forecasts can accelerate public health practitioners' and policy makers' ability to respond to unanticipated shifts in firearm homicides.

Swedo Elizabeth A, Alic Alen, Law Royal K, Sumner Steven A, Chen May S, Zwald Marissa L, Van Dyke Miriam E, Bowen Daniel A, Mercy James A

2023-Mar-01

In JAMA network open

IMPORTANCE : Early detection of attention-deficit/hyperactivity disorder (ADHD) and sleep problems is paramount for children's mental health. Interview-based diagnostic approaches have drawbacks, necessitating the development of an evaluation method that uses digital phenotypes in daily life.

OBJECTIVE : To evaluate the predictive performance of machine learning (ML) models by setting the data obtained from personal digital devices comprising training features (ie, wearable data) and diagnostic results of ADHD and sleep problems by the Kiddie Schedule for Affective Disorders and Schizophrenia Present and Lifetime Version for Diagnostic and Statistical Manual of Mental Disorders, 5th edition (K-SADS) as a prediction class from the Adolescent Brain Cognitive Development (ABCD) study.

DESIGN, SETTING, AND PARTICIPANTS : In this diagnostic study, wearable data and K-SADS data were collected at 21 sites in the US in the ABCD study (release 3.0, November 2, 2020, analyzed October 11, 2021). Screening data from 6571 patients and 21 days of wearable data from 5725 patients collected at the 2-year follow-up were used, and circadian rhythm-based features were generated for each participant. A total of 12 348 wearable data for ADHD and 39 160 for sleep problems were merged for developing ML models.

MAIN OUTCOMES AND MEASURES : The average performance of the ML models was measured using an area under the receiver operating characteristics curve (AUC), sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). In addition, the Shapley Additive Explanations value was used to calculate the importance of features.

RESULTS : The final population consisted of 79 children with ADHD problems (mean [SD] age, 144.5 [8.1] months; 55 [69.6%] males) vs 1011 controls and 68 with sleep problems (mean [SD] age, 143.5 [7.5] months; 38 [55.9%] males) vs 3346 controls. The ML models showed reasonable predictive performance for ADHD (AUC, 0.798; sensitivity, 0.756; specificity, 0.716; PPV, 0.159; and NPV, 0.976) and sleep problems (AUC, 0.737; sensitivity, 0.743; specificity, 0.632; PPV, 0.036; and NPV, 0.992).

CONCLUSIONS AND RELEVANCE : In this diagnostic study, an ML method for early detection or screening using digital phenotypes in children's daily lives was developed. The results support facilitating early detection in children; however, additional follow-up studies can improve its performance.

Kim Won-Pyo, Kim Hyun-Jin, Pack Seung Pil, Lim Jae-Hyun, Cho Chul-Hyun, Lee Heon-Jeong

2023-Mar-01

In Translational vision science & technology

PURPOSE : Our goal was to build a system that combined deep convolutional neural networks (DCNNs) and feature extraction algorithms, which automatically extracted and quantified vascular abnormalities in posterior pole retinal images of full-term infants clinically diagnosed with mild familial exudative retinopathy (FEVR).

METHODS : Using posterior pole retinal images taken from 4628 full-term infants with a total of 9256 eyes, we created data sets, trained DCNNs, and performed tests and comparisons. With the segmented images, our system extracted peripapillary vascular densities, mean tortuosities, and maximum diameter ratios within the region of interest. We also compared them with normal eyes statistically.

RESULTS : In the test data set, the trained system obtained a sensitivity of 0.78 and a specificity of 0.98 for vascular segmentation, with 0.94 and 0.99 for optic disc, respectively. While in the comparison data set, compared with normal, we found a significant increase in vascular densities in retinal images with mild FEVR (5.3211% ± 0.7600% vs. 4.5998% ± 0.6586%) and a significant increase in the maximum diameter ratios (1.8805 ± 0.3197 vs. 1.5087 ± 0.2877), while the mean tortuosities significantly decreased (2.1018 ± 0.2933 [104 cm-3] vs. 3.3344 ± 0.3890 [104 cm-3]). All values were statistically significantly different.

CONCLUSIONS : Our system could automatically segment the posterior pole retinal images and extract from vascular features associated with mild FEVR. Quantitative analysis of these parameters may help ophthalmologists in the early detection of FEVR.

TRANSLATIONAL RELEVANCE : This system may contribute to the early detection of FEVR and facilitate the promotion of artificial intelligence-assisted diagnostic techniques in clinical applications.

Li Peng, Liu Jia

2023-Mar-01

In Medicine

Gültekin Muhammet Zeki, Keskin Zeynep, Dinçel Yaşar Mahsut, Arslan Tuğba

2023-Mar-17