Receive a weekly summary and discussion of the top papers of the week by leading researchers in the field.

ALDH2 as a potential stem cell-related biomarker in lung adenocarcinoma: Comprehensive multi-omics analysis.

In Computational and structural biotechnology journal

Lung adenocarcinoma (LUAD) is the most prevalent lung cancer and one of the leading causes of death. Previous research found a link between LUAD and Aldehyde Dehydrogenase 2 (ALDH2), a member of aldehyde dehydrogenase gene (ALDH) superfamily. In this study, we identified additional useful prognostic markers for early LUAD identification and targeting LUAD therapy by analyzing the expression level, epigenetic mechanism, and signaling activities of ALDH2 in LUAD patients. The obtained results demonstrated that ALDH2 gene and protein expression significantly downregulated in LUAD patient samples. Furthermore, The American Joint Committee on Cancer (AJCC) reported that diminished ALDH2 expression was closely linked to worse overall survival (OS) in different stages of LUAD. Considerably, ALDH2 showed aberrant DNA methylation status in LUAD cancer. ALDH2 was found to be downregulated in the proteomic expression profile of several cell biology signaling pathways, particularly stem cell-related pathways. Finally, the relationship of ALDH2 activity with stem cell-related factors and immune system were reported. In conclusion, the downregulation of ALDH2, abnormal DNA methylation, and the consequent deficit of stemness signaling pathways are relevant prognostic and therapeutic markers in LUAD.

Tran Thi-Oanh, Vo Thanh Hoa, Lam Luu Ho Thanh, Le Nguyen Quoc Khanh

2023

4-HNE, 4-Hydroxynonenal, AJCC, American Joint Committee On Cancer, ALDH, Aldehyde Dehydrogenase, Aldehyde Dehydrogenase 2, CGI, Cpg Island, CPTAC, Clinical Proteomic Tumor Analysis Consortium, CSCs, Cancer Stem Cells, Cancer stem cells, DNA methylation, Gene expression, IHC, Immunohistochemical, LCSCs, Liver Cancer Stem Cells, LUAD, Lung Adenocarcinoma, Lung adenocarcinoma, MAPK, Mitogen-Activated Protein Kinase, MDA, Malondialdehyde, NSCLC, Non-Small Cell Lung Cancer, OS, Overall Survival, Protein expression, ROS, Reactive Oxygen Species, SCLC, Small Cell Lung Cancer, Survival analysis, TCGA, The Cancer Genome Atlas, TMT, Tandem Mass Tags, TNM, Tumor-Node-Metastasis, UICC, International Union For Cancer Control, XRCC1, X-Ray Repair Cross-Complementing Protein 1