In Expert review of vaccines ; h5-index 40.0
BACKGROUND : Monitoring the risk of intussusception after the introduction of rotavirus vaccines is recommended by the World Health Organization (WHO). Although the validity of intussusception monitoring using electronic health records (EHRs) has been confirmed previously, no similar studies have been conducted in China. We aimed to verify the diagnosis and determine an algorithm with the best performance for identification of intussusception using Chinese EHR databases.
RESEARCH DESIGN AND METHODS : Using the Regional Health Information Platform in Ningbo, patients aged 0-72 months from 2015 to 2021 with any related visits for intussusception were included. The algorithms were based on diagnostic codes or keywords in different clinical scenarios, and their performance was evaluated with positive predictive value (PPV) and sensitivity in line with the Brighton guidelines.
RESULTS : Brighton level 1 intussusception was confirmed in 2958 patients with 3246 episodes. Fine-tuned algorithms combining the appearance of the relevant ICD-10 codes or the Chinese keyword 'Chang Tao' in any diagnostic reports with the results of enema treatments or related surgeries showed the highest sensitivity, while the highest PPV was obtained by further criteria based on typical radiographic appearances.
CONCLUSION : Intussusception could be identified and validated internally using EHRs in Ningbo.
Deng Siwei, Liu Zhike, Yang Junting, Zhang Liang, Shou Tiejun, Zhu Jianming, He Yan, Ma Rui, Li Ning, Xu Guozhang, Zhan Siyan
2023
Algorithms, China, electronic health records, intussusception, post-market monitoring, verification study
