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Plasma extracellular vesicles and cell-free mitochondrial DNA are associated with cognitive dysfunction in treated older adults with HIV.

In Journal of neurovirology

Extracellular vesicles (EVs) are nanoparticles with a role in intercellular communication. Cell-free mitochondrial DNA (cf-mtDNA) has been associated with cognitive dysfunction in people with HIV (PWH). We conducted a nested case-control study to test the hypothesis that plasma EVs are associated with cf-mtDNA and cognitive dysfunction in older PWH. A machine learning-based model identified total EVs, including select EV subpopulations, as well as urine cf-mtDNA and 4-meter walk time carry power to predict the neurocognitive impairment. These features resulted in an AUC-ROC of 0.845 + / - 0.109 (0.615, 1.00).

Johnston Carrie D, de Menezes Erika G Marques, Bowler Scott, Siegler Eugenia L, Friday Courtney, Norris Philip J, Rice Michelle C, Choi Mary E, Glesby Marshall J, Ndhlovu Lishomwa C

2023-Mar-18

Aging, Cognition, Extracellular vesicles, Frailty, HIV, Inflammation, Mitochondria