In European journal of nuclear medicine and molecular imaging ; h5-index 66.0
PURPOSE : Postoperative early recurrence (ER) leads to a poor prognosis for intrahepatic cholangiocarcinoma (ICC). We aimed to develop machine learning (ML) radiomics models to predict ER in ICC after curative resection.
METHODS : Patients with ICC undergoing curative surgery from three institutions were retrospectively recruited and assigned to training and external validation cohorts. Preoperative arterial and venous phase contrast-enhanced computed tomography (CECT) images were acquired and segmented. Radiomics features were extracted and ranked through their importance. Univariate and multivariate logistic regression analysis was used to identify clinical characteristics. Various ML algorithms were used to construct radiomics-based models, and the predictive performance was evaluated by receiver operating characteristic curves, calibration curves, and decision curve analysis.
RESULTS : 127 patients were included for analysis: 90 patients in the training set and 37 patients in the validation set. Ninety-two patients (72.4%) experienced recurrence, including 71 patients exhibiting ER. Male sex, microvascular invasion, TNM stage, and serum CA19-9 were identified as independent risk factors for ER, with the corresponding clinical model having a poor predictive performance (AUC of 0.685). Fifty-seven differential radiomics features were identified, and the 10 most important features were utilized for modelling. Seven ML radiomics models were developed with a mean AUC of 0.87 ± 0.02, higher than the clinical model. Furthermore, the clinical-radiomics models showed similar predictive performance to the radiomics models (AUC of 0.87 ± 0.03).
CONCLUSION : ML radiomics models based on CECT are valuable in predicting ER in ICC.
Bo Zhiyuan, Chen Bo, Yang Yi, Yao Fei, Mao Yicheng, Yao Jiangqiao, Yang Jinhuan, He Qikuan, Zhao Zhengxiao, Shi Xintong, Chen Jicai, Yu Zhengping, Yang Yunjun, Wang Yi, Chen Gang
2023-Mar-16
Contrast-enhanced computed tomography, Early recurrence, Intrahepatic cholangiocarcinoma, Machine learning, Radiomics
