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Computational prediction of interactions between Paxlovid and prescription drugs.

In Proceedings of the National Academy of Sciences of the United States of America

Pfizer's Paxlovid has recently been approved for the emergency use authorization (EUA) from the US Food and Drug Administration (FDA) for the treatment of mild-to-moderate COVID-19. Drug interactions can be a serious medical problem for COVID-19 patients with underlying medical conditions, such as hypertension and diabetes, who have likely been taking other drugs. Here, we use deep learning to predict potential drug-drug interactions between Paxlovid components (nirmatrelvir and ritonavir) and 2,248 prescription drugs for treating various diseases.

Kim Yeji, Ryu Jae Yong, Kim Hyun Uk, Lee Sang Yup

2023-Mar-21

COVID-19, DeepDDI2, Paxlovid, drug interactions