In Journal of affective disorders ; h5-index 79.0
BACKGROUND : Cerebral specialization is an important functional architecture of the human brain. Abnormal cerebral specialization may be the underlying pathogenesis of obsessive-compulsive disorder (OCD). Resting-state functional magnetic resonance imaging (rs-fMRI) was used to show that the specialization pattern of OCD was of great significance for early warning and precise intervention of the disease.
METHOD : The autonomy index (AI) based on the rs-fMRI was calculated to compare brain specializations between 80 OCD patients and 81 matched healthy controls (HCs). In addition, we also correlated the AI alteration patterns with neurotransmitter receptor/transporter densities.
RESULTS : OCD patients showed increased AI in the right insula and right superior temporal gyrus when compared with HCs. In addition, AI differences were associated with serotonin receptors (5-HT1AR and 5HT4R), dopamine D2 receptors, norepinephrine transporters, and metabotropic glutamate receptor densities.
LIMITATIONS : Drug effect; cross-sectional study design; the selection of positron emission tomography template.
CONCLUSIONS : This study showed abnormal specialization patterns in OCD patients, which may lead to the elucidation of the underlying pathological mechanism of the disease.
Liu Yueling, Sun Jinmei, Jiang Jin, Wan Ke, Tang Yan, Zhang Mengzhu, Chen Lu, Hua Qiang, Fang Wenmei, Zhu Chunyan, Wang Kai
2023-Mar-03
Cerebral specialization, Neurotransmitters receptors/transporters, Obsessive-compulsive disorder, Resting-state functional magnetic resonance imaging
