In American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
In heart transplantation, the use of biomarkers to detect the risk of rejection has been evolving. In this setting, it is becoming less clear as to what is the most reliable test or combination of tests to detect rejection and to assess the state of the alloimmune response. Therefore, a virtual expert panel was organized in heart and kidney transplantation to evaluate emerging diagnostics and how they may be best utilized to monitor and manage transplant patients. This manuscript covers the heart content of the conference and is a work product of the American Society of Transplantation's Thoracic and Critical Care Community of Practice. This paper reviews currently available and emerging diagnostic assays and defines the unmet needs for biomarkers in heart transplantation. Highlights of the in-depth discussions among conference participants that led to development of consensus statements are included. This conference should serve as a platform to further build consensus within the heart transplant community regarding the optimal framework to implement biomarkers into management protocols and to improve biomarker development, validation and clinical utility. Ultimately, these biomarkers and novel diagnostics should improve outcomes and optimize quality of life for our transplant patients.
Kobashigawa Jon, Hall Shelley, Shah Palak, Fine Barry, Halloran Phil, Jackson Annette M, Khush Kiran K, Margulies Kenneth B, Sani Maryam Mojarrad, Patel Jignesh K, Patel Nikhil, Peyster Eliot
2023-Mar-02
Heart transplantation, biomarkers, cell-free DNA, genomics, machine learning, microRNA, outcomes
