In Cell reports ; h5-index 119.0
Inflammatory stimuli cause a state of emergency myelopoiesis leading to neutrophil-like monocyte expansion. However, their function, the committed precursors, or growth factors remain elusive. In this study we find that Ym1+Ly6Chi monocytes, an immunoregulatory entity of neutrophil-like monocytes, arise from progenitors of neutrophil 1 (proNeu1). Granulocyte-colony stimulating factor (G-CSF) favors the production of neutrophil-like monocytes through previously unknown CD81+CX3CR1lo monocyte precursors. GFI1 promotes the differentiation of proNeu2 from proNeu1 at the cost of producing neutrophil-like monocytes. The human counterpart of neutrophil-like monocytes that also expands in response to G-CSF is found in CD14+CD16- monocyte fraction. The human neutrophil-like monocytes are discriminated from CD14+CD16- classical monocytes by CXCR1 expression and the capacity to suppress T cell proliferation. Collectively, our findings suggest that the aberrant expansion of neutrophil-like monocytes under inflammatory conditions is a process conserved between mouse and human, which may be beneficial for the resolution of inflammation.
Ikeda Naoki, Kubota Hiroaki, Suzuki Risa, Morita Mitsuki, Yoshimura Ayana, Osada Yuya, Kishida Keigo, Kitamura Daiki, Iwata Ayaka, Yotsumoto Satoshi, Kurotaki Daisuke, Nishimura Koutarou, Nishiyama Akira, Tamura Tomohiko, Kamatani Takashi, Tsunoda Tatsuhiko, Murakawa Miyako, Asahina Yasuhiro, Hayashi Yoshihiro, Harada Hironori, Harada Yuka, Yokota Asumi, Hirai Hideyo, Seki Takao, Kuwahara Makoto, Yamashita Masakatsu, Shichino Shigeyuki, Tanaka Masato, Asano Kenichi
2023-Feb-28
CP: Immunology, CXCR1, G-CSF, Ym1, demand-adapted myelopoiesis, emergency myelopoiesis, machine learning, monocyte, neutrophil-like monocyte, ontogeny
