ArXiv Preprint
Brain disorders in the early and late life of humans potentially share
pathological alterations in brain functions. However, the key evidence from
neuroimaging data for pathological commonness remains unrevealed. To explore
this hypothesis, we build a deep learning model, using multi-site functional
magnetic resonance imaging data (N=4,410, 6 sites), for classifying 5 different
brain disorders from healthy controls, with a set of common features. Our model
achieves 62.6(1.9)% overall classification accuracy on data from the 6
investigated sites and detects a set of commonly affected functional
subnetworks at different spatial scales, including default mode, executive
control, visual, and limbic networks. In the deep-layer feature representation
for individual data, we observe young and aging patients with disorders are
continuously distributed, which is in line with the clinical concept of the
"spectrum of disorders". The revealed spectrum underlying early- and late-life
brain disorders promotes the understanding of disorder comorbidities in the
lifespan.
Mianxin Liu, Jingyang Zhang, Yao Wang, Yan Zhou, Fang Xie, Qihao Guo, Feng Shi, Han Zhang, Qian Wang, Dinggang Shen
2023-02-23
