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Polygenic score development in the era of large-scale biobanks.

In Cell genomics

In this issue of Cell Genomics, Xu et al. report a comprehensive analysis of the genetics of 26 blood cell traits, leveraging data from two large biobanks to construct and make available machine-learning optimized polygenic scores (PGSs). In addition to delivering insights into the biology and clinical associations of these traits, the authors evaluate and provide recommendations on methods for PGS construction.

Plagnol Vincent

2022-Jan-12