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Deep learning enables fast, gentle STED microscopy.

In bioRxiv : the preprint server for biology

STED microscopy is widely used to image subcellular structures with super-resolution. Here, we report that denoising STED images with deep learning can mitigate photobleaching and photodamage by reducing the pixel dwell time by one or two orders of magnitude. Our method allows for efficient and robust restoration of noisy 2D and 3D STED images with multiple targets and facilitates long-term imaging of mitochondrial dynamics.

Ebrahimi Vahid, Stephan Till, Kim Jiah, Carravilla Pablo, Eggeling Christian, Jakobs Stefan, Han Kyu Young

2023-Jan-27