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In Telemedicine journal and e-health : the official journal of the American Telemedicine Association

Purpose: Diabetic retinopathy (DR) is a microvascular complication of diabetes mellitus (DM). Standard of care for patients with DM is an annual eye examination or retinal imaging to assess for DR, the latter of which may be completed through telemedicine approaches. One significant issue is poor-quality images that prevent adequate screening and are thus ungradable. We used artificial intelligence to enable point-of-care (at time of imaging) identification of ungradable images in a DR screening program. Methods: Nonmydriatic retinal images were gathered from patients with DM imaged during a primary care or endocrinology visit from September 1, 2017, to June 1, 2021. The Topcon TRC-NW400 retinal camera (Topcon Corp., Tokyo, Japan) was used. Images were interpreted by 5 ophthalmologists for gradeability, presence and stage of DR, and presence of non-DR pathologies. A convolutional neural network with Inception V3 network architecture was trained to assess image gradeability. Images were divided into training and test sets, and 10-fold cross-validation was performed. Results: A total of 1,377 images from 537 patients (56.1% female, median age 58) were analyzed. Ophthalmologists classified 25.9% of images as ungradable. Of gradable images, 18.6% had DR of varying degrees and 26.5% had non-DR pathology. 10 fold cross-validation produced an average area under receiver operating characteristic curve (AUC) of 0.922 (standard deviation: 0.027, range: 0.882 to 0.961). The final model exhibited similar test set performance with an AUC of 0.924. Conclusions: This model accurately assesses gradeability of nonmydriatic retinal images. It could be used for increasing the efficiency of DR screening programs by enabling point-of-care identification of poor-quality images.

Bryan John M, Bryar Paul J, Mirza Rukhsana G

2023-Feb-02

artificial intelligence, diabetic retinopathy, image quality, retina, screening, telemedicine