Receive a weekly summary and discussion of the top papers of the week by leading researchers in the field.

In Bioinformatics (Oxford, England)

MOTIVATION : Recently, deep learning has become the mainstream methodology for Drug-Target binding Affinity (DTA) prediction. However, two deficiencies of the existing methods restrict their practical applications. On the one hand, most existing methods ignore the individual information of sequence elements, resulting in poor sequence feature representations. On the other hand, without prior biological knowledge, the prediction of drug-target binding regions based on attention weights of a deep neural network could be difficult to verify, which may bring adverse interference to biological researchers.

RESULTS : We propose a novel Multi-Functional and Robust Drug-Target binding Affinity prediction (MFR-DTA) method to address the above issues. Specifically, we design a new biological sequence feature extraction block, namely BioMLP, that assists the model in extracting individual features of sequence elements. Then, we propose a new Elem-feature fusion block to refine the extracted features. After that, we construct a Mix-Decoder block that extracts drug-target interaction information and predicts their binding regions simultaneously. Last, we evaluate MFR-DTA on two benchmarks consistently with the existing methods and propose a new dataset, sc-PDB, to better measure the accuracy of binding region prediction. We also visualise some samples to demonstrate the locations of their binding sites and the predicted multi-scale interaction regions. The proposed method achieves excellent performance on these datasets, demonstrating its merits and superiority over the state-of-the-art methods.

AVAILABILITY AND IMPLEMENTATION : https://github.com/JU-HuaY/MFR.

SUPPLEMENTARY INFORMATION : Supplementary data are available at Bioinformatics online.

Hua Yang, Song Xiaoning, Feng Zhenhua, Wu Xiaojun

2023-Jan-27