In American journal of ophthalmology ; h5-index 67.0
PURPOSE : To compare the performance of two relatively recent geometric deep learning techniques in diagnosing glaucoma from a single OCT scan of the ONH; and (2) To identify the three-dimensional (3D) structural features of the ONH that are critical for the diagnosis of glaucoma.
DESIGN : Comparison and evaluation of deep learning diagnostic algorithms.
METHODS : In this study, we included a total of 2,247 non-glaucoma and 2,259 glaucoma scans from 1,725 subjects. All subjects had their ONHs imaged in 3D with Spectralis OCT. All OCT scans were automatically segmented using deep learning to identify major neural and connective tissues. Each ONH was then represented as a 3D point cloud. We used PointNet and dynamic graph convolutional neural network (DGCNN) to diagnose glaucoma from such 3D ONH point clouds and to identify the critical 3D structural features of the ONH for glaucoma diagnosis.
RESULTS : Both the DGCNN (AUC: 0.97±0.01) and PointNet (AUC: 0.95±0.02) were able to accurately detect glaucoma from 3D ONH point clouds. The critical points (i.e. critical structural features of the ONH) formed an hourglass pattern with most of them located within the neuro-retinal rim in the inferior and superior quadrant of the ONH.
CONCLUSIONS : The diagnostic accuracy of both geometric deep learning approaches was excellent. Moreover, we were able to identify the critical 3D structural features of the ONH for glaucoma diagnosis that tremendously improved the transparency and interpretability of our method. Consequently, our approach may have strong potential to be used in clinical applications for the diagnosis and prognosis of a wide range of ophthalmic disorders.
Braeu Fabian A, Thiéry Alexandre H, Tun Tin A, Kadziauskiene Aiste, Barbastathis George, Aung Tin, Girard Michaël J A
2023-Jan-13
Geometric deep learning, Optic Nerve Head, PointNet, artificial intelligence, glaucoma
