In PeerJ
To improve the accuracy of preoperative diagnoses and avoid over- or undertreatment, we aimed to develop and compare computed tomography-based radiomics machine learning models for the prediction of histological invasiveness using sub-centimeter subsolid pulmonary nodules. Three predictive models based on radiomics were built using three machine learning classifiers to discriminate the invasiveness of the sub-centimeter subsolid pulmonary nodules. A total of 203 sub-centimeter nodules from 177 patients were collected and assigned randomly to the training set (n = 143) or test set (n = 60). The areas under the curve of the predictive models were 0.743 (95% confidence interval CI [0.661-0.824]) for the logistic regression, 0.828 (95% CI [0.76-0.896]) for the support vector machine, and 0.917 (95% CI [0.869-0.965]) for the XGBoost classifier models in the training set, and 0.803 (95% CI [0.694-0.913]), 0.726 (95% CI [0.598-0.854]), and 0.874 (95% CI [0.776-0.972]) in the test set, respectively. In addition, the decision curve showed that the XGBoost model added more net benefit within the range of 0.06 to 0.93.
Zhang Haochuan, Wang Shixiong, Deng Zhenkai, Li Yangli, Yang Yingying, Huang He
2023
CT images, Invasiveness, Machine learning, Radiomics, Sub-centimeter subsolid pulmonary nodules
