In Intelligence-based medicine
Acute Respiratory Distress Syndrome (ARDS) is associated with high morbidity and mortality. Identification of ARDS enables lung protective strategies, quality improvement interventions, and clinical trial enrolment, but remains challenging particularly in the first 24 h of mechanical ventilation. To address this we built an algorithm capable of discriminating ARDS from other similarly presenting disorders immediately following mechanical ventilation. Specifically, a clinical team examined medical records from 1263 ICU-admitted, mechanically ventilated patients, retrospectively assigning each patient a diagnosis of "ARDS" or "non-ARDS" (e.g., pulmonary edema). Exploiting data readily available in the clinical setting, including patient demographics, laboratory test results from before the initiation of mechanical ventilation, and features extracted by natural language processing of radiology reports, we applied an iterative pre-processing and machine learning framework. The resulting model successfully discriminated ARDS from non-ARDS causes of respiratory failure (AUC = 0.85) among patients meeting Berlin criteria for severe hypoxia. This analysis also highlighted novel patient variables that were informative for identifying ARDS in ICU settings.
Afshin-Pour Babak, Qiu Michael, Hosseini Shahrzad, Cheyne Helen, Ha Kevin, Stewart Molly, Horsky Jan, Aviv Rachel, Zhang Nasen, Narasimhan Mangala, Chelico John, Musso Gabriel, Hajizadeh Negin
2023-Jan-05
Acute Respiratory Distress Syndrome, Natural language processing, Supervised machine learning
