In Computers in biology and medicine
Automatic retinal blood vessel segmentation is a key link in the diagnosis of ophthalmic diseases. Recent deep learning methods have achieved high accuracy in vessel segmentation but still face challenges in maintaining vascular structural connectivity. Therefore, this paper proposes a novel retinal blood vessel segmentation strategy that includes three stages: vessel structure detection, vessel branch extraction and broken vessel segment reconnection. First, we propose a multiscale linear structure detection network (MS-LSDNet), which improves the detection ability of fine blood vessels by learning the types of rich hierarchical features. In addition, to maintain the connectivity of the vascular structure in the process of binarization of the vascular probability map, an adaptive hysteresis threshold method for vascular extraction is proposed. Finally, we propose a vascular tree structure reconstruction algorithm based on a geometric skeleton to connect the broken vessel segments. Experimental results on three publicly available datasets show that compared with current state-of-the-art algorithms, our strategy effectively maintains the connectivity of retinal vascular tree structure.
Du Hongwei, Zhang Xinyue, Song Gang, Bao Fangxun, Zhang Yunfeng, Wu Wei, Liu Peide
2022-Dec-28
Deep learning, Fundus images, Vessel reconnection, Vessel segmentation
