In Patterns (New York, N.Y.)
Pathologists diagnose prostate cancer by core needle biopsy. In low-grade and low-volume cases, they look for a few malignant glands out of hundreds within a core. They may miss a few malignant glands, resulting in repeat biopsies or missed therapeutic opportunities. This study developed a multi-resolution deep-learning pipeline to assist pathologists in detecting malignant glands in core needle biopsies of low-grade and low-volume cases. Analyzing a gland at multiple resolutions, our model exploited morphology and neighborhood information, which were crucial in prostate gland classification. We developed and tested our pipeline on the slides of a local cohort of 99 patients in Singapore. Besides, we made the images publicly available, becoming the first digital histopathology dataset of patients of Asian ancestry with prostatic carcinoma. Our multi-resolution classification model achieved an area under the receiver operating characteristic curve (AUROC) value of 0.992 (95% confidence interval [CI]: 0.985-0.997) in the external validation study, showing the generalizability of our multi-resolution approach.
Oner Mustafa Umit, Ng Mei Ying, Giron Danilo Medina, Chen Xi Cecilia Ee, Yuan Xiang Louis Ang, Singh Malay, Yu Weimiao, Sung Wing-Kin, Wong Chin Fong, Lee Hwee Kuan
2022-Dec-09
artificial intelligence, computational pathology, deep learning, digital pathology, histopathology, machine learning, prostate cancer, whole slide image analysis
