In STAR protocols
Investigating network behavior from host-pathogen interactions is challenging. Here, we present the deep-learning-based protocol to construct an immune-related gene network and list the genes involved in the defense response of host to specific biotic stress. The protocol includes the steps to pre-process the interaction pairs and expression profile of plants treated with pathogen/control, feed as input for DLNet algorithm to rank genes based on their contribution to data classification. The top-ranked genes are subjected to module and enrichment analysis. For complete details on the use and execution of this protocol, please refer to Kumar et al. (2022).1.
Kumar Ravi, Acharya Vishal
2022-Dec-14
Bioinformatics, Computer sciences, Genomics, Immunology, Microbiology, Plant sciences, Systems biology
