In Frontiers in immunology ; h5-index 100.0
INTRODUCTION : Rheumatoid arthritis (RA), a prevailing chronic progressive autoimmune disease, seriously affects the patient's quality of life. However, there is still a lack of precise treatment and management methods in clinical practice. Previous studies showed that CD8+ T cells take a lead in the progression of RA.
METHODS : Genes closely related to CD8+T cells in RA were identified through multiple RA datasets, CIBERSORT, and WGCNA algorithms. Further machine learning analysis were performed to identify CD8+T cell-related genes most closely related to RA. In addition, the relationship between these three key genes and 33 cancer species was also explored in this study.
RESULTS : In this study, 10 genes were identified to be closely related to CD8+T cells in RA. Machine learning analysis identified 3 CD8+T cell-related genes most closely related to RA: CD8A, GZMA, and PRF1.
DISCUSSION : Our research aims to provide new ideas for the clinical treatment of RA.
Zhao Zhenyu, Ren Jie, Xie Siping, Zou Longchun, Zhao Qianyue, Zeng Shan, Zha Dingsheng
2022
CD8+ T Cells1, Pan-Cancer4, WGCNA3, rheumatoid arthritis2, ssGSEA5
