In Japanese journal of clinical oncology
BACKGROUND : The importance of the stromal components in tumour progression has been discussed widely, but their prognostic role in small size tumours with lepidic components is not fully understood. Applying digital tissue image analysis to whole-slide imaging may enhance the accuracy and reproducibility of pathological assessment. This study aimed to evaluate the prognostic value of tumour components of lung adenocarcinoma by measuring the dimensions of the tumour consisting elements separately, using a machine learning algorithm.
METHODS : Between September 2002 and December 2016, 317 patients with surgically resected, pathological stage IA adenocarcinoma with lepidic components were analysed. We assessed the whole tumour area, including the lepidic components, and measured the epithelium, collagen, elastin areas and alveolar air space. We analysed the prognostic impact of each tumour component.
RESULTS : The dimensions of the epithelium and collagen areas were independent significant risk factors for recurrence-free survival (hazard ratio, 8.38; 95% confidence interval, 1.14-61.88; P = 0.037, and hazard ratio, 2.58; 95% confidence interval, 1.14-5.83; P = 0.022, respectively). According to the subgroup analysis when combining the epithelium and collagen areas as risk factors, patients with tumours consisting of both large epithelium and collagen areas showed significantly poor prognoses (P = 0.002).
CONCLUSIONS : We assessed tumour components using a machine learning algorithm to stratify the post-operative prognosis of surgically resected stage IA adenocarcinomas. This method might guide the selection of patients with a high risk of recurrence.
Terada Yukihiro, Isaka Mitsuhiro, Kawata Takuya, Mizuno Kiyomichi, Muramatsu Koji, Katsumata Shinya, Konno Hayato, Nagata Toshiyuki, Mizuno Tetsuya, Serizawa Masakuni, Ono Akira, Sugino Takashi, Shimizu Kimihiro, Ohde Yasuhisa
2022-Dec-02
lung adenocarcinoma, machine learning, prognosis, tumour components, whole-slide imaging
