In Bioinformatics (Oxford, England)
SUMMARY : The Artificial Intelligence-based structure prediction program AlphaFold-Multimer enabled structural modelling of protein complexes with unprecedented accuracy. Increasingly, AlphaFold-Multimer is also used to discover new protein-protein interactions. Here, we present AlphaPulldown, a Python package that streamlines protein-protein interaction screens and high-throughput modelling of higher-order oligomers using AlphaFold-Multimer. It provides a convenient command line interface, a variety of confidence scores, and a graphical analysis tool.
AVAILABILITY : AlphaPulldown is freely available at https://www.embl-hamburg.de/AlphaPulldown.
SUPPLEMENTARY INFORMATION : Supplementary note is available at Bioinformatics online.
Yu Dingquan, Chojnowski Grzegorz, Rosenthal Maria, Kosinski Jan
2022-Nov-22
