Three-dimensional amide proton transfer-weighted and intravoxel incoherent motion imaging for predicting bone metastasis in patients with prostate cancer: A pilot study.

In Magnetic resonance imaging

PURPOSE : To explore the value of 3-dimensional amide proton transfer-weighted (APTw) and intravoxel incoherent motion (IVIM) imaging in predicting bone metastasis (BM) of prostate cancer (PCa) in addition to routine diffusion-weighted imaging (DWI).

METHODS : The clinical and imaging data of 39 PCa patients who were pathologically confirmed in our hospital from March 2019 to February 2022 were retrospectively analyzed, and they were divided into BM-negative (27 patients) and BM-positive (12 patients) groups. MR examination included APTw, DWI and IVIM imaging. The IVIM data was fitted by single-exponential IVIM model (IVIM_mono) and double-exponential IVIM model (IVIM_bi), respectively. The APTw, ADC, IVIM_mono (D_mono, D*_mono, and f_mono), and IVIM_bi (D_bi, D*_bi, and f_bi) parameters were independently measured by two radiologists. The synthetic minority oversampling technique (SMOTE) was conducted to balance the minority group. Mann-Whitney U test or Student's t-test was used to compare above values between the BM-negative and BM-positive groups. The diagnostic performance was evaluated with receiver operating characteristic (ROC) analysis of each parameter and their combination. The Delong test was used for ROC curve comparison.The relationship between APTw and IVIM was explored through Spearman's rank correlation analysis.

RESULTS : The APTw and D*_mono values were higher, and the ADC, f_mono, and f_bi values were lower in the BM-positive group than in the BM-negative group (all P < 0.05). Among the individual parameters, the AUC of f_mono was the highest (AUC = 0.865), and AUC (f_mono) was significantly higher than AUC (f_bi), AUC (D*_mono), and AUC (ADC) (all P < 0.05). The AUC (IVIM_mono) was higher than the AUC (IVIM_bi) (P = 0.0068). The combination of APTw and IVIM_mono further improved diagnostic capability, and the AUC of APTw+IVIM_mono was significantly higher than those of APTw and DWI (all P < 0.05). No correlation was found between IVIM-derived parameters and APTw value.

CONCLUSION : Both 3D APTw and IVIM imaging could predict BM of PCa. IVIM showed better performance than APTw and DWI, and the single-exponential IVIM model was superior to the double-exponential IVIM model. The combination of APTw and IVIM could further improve diagnostic performance.

Hu Wenjun, Chen Lihua, Lin Liangjie, Wang Jiazheng, Wang Nan, Liu Ailian

2022-Nov-11

Amide proton transfer-weighted, Bone metastasis, Intravoxel incoherent motion, Predicting, Prostate cancer