In International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
BACKGROUND : Rabies is an acute lethal infectious disease caused by lyssavirus infection. In 2018, the World Health Organization (WHO) proposed a global strategic plan to end human rabies deaths by 2030. However, systematic studies of the global rabies disease burden and epidemiological trends are scarce.
METHODS : We extracted the disease burden and epidemiological data of global rabies in the preceding 30 years from the Global Burden of Disease (GBD) study 2019 and performed a comprehensive analysis.
RESULTS : In 2019, the incident cases of rabies worldwide were 14075.51 (95% uncertainty interval, UI: 6124.33-21618.11), and the number of deaths was 13743.44 (95%UI: 6019.13-17938.53), both of which were lower than that in 1990. With the improvement of the Socio-demographic Index (SDI), the incident cases, the number of deaths, age-standardized incidence rate (ASIR) and death rate (ASDR), and disability-adjusted life years (DALYs) of rabies all showed downward trends. Adolescents and adults under the age of 50 represented the majority of rabies cases worldwide.
CONCLUSIONS : The global disease burden of rabies had declined over the past 30 years. Furthermore, the disease burden of rabies was closely related to the SDI level.
Gan Hui, Hou Xiangqing, Wang Yiming, Xu Gaofeng, Huang Zhifeng, Zhang Teng, Lin Runpei, Xue Mingshan, Hu Haisheng, Liu Mingtao, Cheng Zhangkai J, Sun Baoqing, Zhu Zheng
2022-Nov-04
disability-adjusted life years, global disease burden, mortality, prevalence, rabies
