Receive a weekly summary and discussion of the top papers of the week by leading researchers in the field.

CNNArginineMe: A CNN structure for training models for predicting arginine methylation sites based on the One-Hot encoding of peptide sequence.

In Frontiers in genetics ; h5-index 62.0

Protein arginine methylation (PRme), as one post-translational modification, plays a critical role in numerous cellular processes and regulates critical cellular functions. Though several in silico models for predicting PRme sites have been reported, new models may be required to develop due to the significant increase of identified PRme sites. In this study, we constructed multiple machine-learning and deep-learning models. The deep-learning model CNN combined with the One-Hot coding showed the best performance, dubbed CNNArginineMe. CNNArginineMe performed best in AUC scoring metrics in comparisons with several reported predictors. Additionally, we employed CNNArginineMe to predict arginine methylation proteome and performed functional analysis. The arginine methylated proteome is significantly enriched in the amyotrophic lateral sclerosis (ALS) pathway. CNNArginineMe is freely available at https://github.com/guoyangzou/CNNArginineMe.

Zhao Jiaojiao, Jiang Haoqiang, Zou Guoyang, Lin Qian, Wang Qiang, Liu Jia, Ma Leina

2022

CNNArginineMe, amyotrophic lateral sclerosis (ALS) pathway, arginine methylation, deep learning model, machine learning