ArXiv Preprint
Despite their remarkable performance, deep neural networks remain unadopted
in clinical practice, which is considered to be partially due to their lack in
explainability. In this work, we apply attribution methods to a pre-trained
deep neural network (DNN) for 12-lead electrocardiography classification to
open this "black box" and understand the relationship between model prediction
and learned features. We classify data from a public data set and the
attribution methods assign a "relevance score" to each sample of the classified
signals. This allows analyzing what the network learned during training, for
which we propose quantitative methods: average relevance scores over a)
classes, b) leads, and c) average beats. The analyses of relevance scores for
atrial fibrillation (AF) and left bundle branch block (LBBB) compared to
healthy controls show that their mean values a) increase with higher
classification probability and correspond to false classifications when around
zero, and b) correspond to clinical recommendations regarding which lead to
consider. Furthermore, c) visible P-waves and concordant T-waves result in
clearly negative relevance scores in AF and LBBB classification, respectively.
In summary, our analysis suggests that the DNN learned features similar to
cardiology textbook knowledge.
Theresa Bender, Jacqueline Michelle Beinecke, Dagmar Krefting, Carolin Müller, Henning Dathe, Tim Seidler, Nicolai Spicher, Anne-Christin Hauschild
2022-11-03
