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In Journal of neurosurgery. Spine

OBJECTIVE : Prior studies have revealed that a body mass index (BMI) ≥ 30 is associated with worse outcomes following surgical intervention in grade 1 lumbar spondylolisthesis. Using a machine learning approach, this study aimed to leverage the prospective Quality Outcomes Database (QOD) to identify a BMI threshold for patients undergoing surgical intervention for grade 1 lumbar spondylolisthesis and thus reliably identify optimal surgical candidates among obese patients.

METHODS : Patients with grade 1 lumbar spondylolisthesis and preoperative BMI ≥ 30 from the prospectively collected QOD lumbar spondylolisthesis module were included in this study. A 12-month composite outcome was generated by performing principal components analysis and k-means clustering on four validated measures of surgical outcomes in patients with spondylolisthesis. Random forests were generated to determine the most important preoperative patient characteristics in predicting the composite outcome. Recursive partitioning was used to extract a BMI threshold associated with optimal outcomes.

RESULTS : The average BMI was 35.7, with 282 (46.4%) of the 608 patients from the QOD data set having a BMI ≥ 30. Principal components analysis revealed that the first principal component accounted for 99.2% of the variance in the four outcome measures. Two clusters were identified corresponding to patients with suboptimal outcomes (severe back pain, increased disability, impaired quality of life, and low satisfaction) and to those with optimal outcomes. Recursive partitioning established a BMI threshold of 37.5 after pruning via cross-validation.

CONCLUSIONS : In this multicenter study, the authors found that a BMI ≤ 37.5 was associated with improved patient outcomes following surgical intervention. These findings may help augment predictive analytics to deliver precision medicine and improve prehabilitation strategies.

Agarwal Nitin, Aabedi Alexander A, Chan Andrew K, Letchuman Vijay, Shabani Saman, Bisson Erica F, Bydon Mohamad, Glassman Steven D, Foley Kevin T, Shaffrey Christopher I, Potts Eric A, Shaffrey Mark E, Coric Domagoj, Knightly John J, Park Paul, Wang Michael Y, Fu Kai-Ming, Slotkin Jonathan R, Asher Anthony L, Virk Michael S, Haid Regis W, Chou Dean, Mummaneni Praveen V


Quality Outcomes Database, lumbar, machine learning, obesity, spondylolisthesis