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In Computer methods and programs in biomedicine

PURPOSE : Currently, Computed Tomography Angiography (CTA) is the most commonly used clinical method for the diagnosis of aortic dissection, which is much better than plain CT. However, CTA examination has some disadvantages such as time-consuming image processing, complicated procedure and injection of developer. CT plain scanning is widely used in the early diagnosis of arterial dissection because of its convenience, speed and popularity. In order not to delay the optimal diagnosis and treatment time of patients, we use deep learning technology and network model to synthesize plain CT images into CTA images. Patients can be timely professional related departments of clinical diagnosis and treatment, and reduce the rate of missed diagnosis. In this paper, we propose a CTA image synthesis technique for cardiac aortic dissection based on the cascaded generative adjunctive network model.

METHOD : Firstly, we registered CT images, and then used nnU-Net segmentation network model to obtain CT and CTA paired images containing only the aorta. Then we proposed a CTA image synthesis method for aortic dissection based on cascaded generative adversarial. The core idea is to build a cascade generator and double discriminator network based on DCT channel attention mechanism to further enhance the synthesis effect of CTA.

RESULTS : The model is trained and tested on CT plain scan and CTA image data set of aortic dissection. The results show that the proposed model achieves good results in CTA image synthesis. In the CT data set, the nnU-Net model improves 8.63% and reduces 10.87mm errors in the key index DSC and HD, respectively, compared with the benchmark model U-Net. In CTA data set, nnU-Net model improves 10.27% and reduces 6.56mm error in key index DSC and HD, respectively, compared with benchmark model U-Net. In the synthesis task, the cascaded generative adm network is superior to Pix2pix and Pix2pixHD network models in both PSNR and SSIM, which proves that our proposed model has significant advantages.

CONCLUSION : This study provides new possibilities for CTA image synthesis of aortic dissection, and improves the accuracy and efficiency of diagnosis, and hopes to provide substantial help for the diagnosis of aortic dissection.

Chen Hongwei, Yan Sunang, Xie Mingxing, Huang Jianlong


Aortic dissection, Attention mechanism, CT, CTA synthesis technology, GAN