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In Cerebral cortex (New York, N.Y. : 1991)

It is well documented that some brain regions, such as association cortices, caudate, and hippocampus, are particularly prone to age-related atrophy, but it has been hypothesized that there are individual differences in atrophy profiles. Here, we document heterogeneity in regional-atrophy patterns using latent-profile analysis of 1,482 longitudinal magnetic resonance imaging observations. The results supported a 2-group solution reflecting differences in atrophy rates in cortical regions and hippocampus along with comparable caudate atrophy. The higher-atrophy group had the most marked atrophy in hippocampus and also lower episodic memory, and their normal caudate atrophy rate was accompanied by larger baseline volumes. Our findings support and refine models of heterogeneity in brain aging and suggest distinct mechanisms of atrophy in striatal versus hippocampal-cortical systems.

Nyberg Lars, Andersson Micael, Lundquist Anders, Baaré William F C, Bartrés-Faz David, Bertram Lars, Boraxbekk Carl-Johan, Brandmaier Andreas M, Demnitz Naiara, Drevon Christian A, Duezel Sandra, Ebmeier Klaus P, Ghisletta Paolo, Henson Richard, Jensen Daria E A, Kievit Rogier A, Knights Ethan, Kühn Simone, Lindenberger Ulman, Plachti Anna, Pudas Sara, Roe James M, Madsen Kathrine Skak, Solé-Padullés Cristina, Sommerer Yasmine, Suri Sana, Zsoldos Enikő, Fjell Anders M, Walhovd Kristine B


aging, caudate, cortex, hippocampus, individual differences