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In Bioinformatics (Oxford, England)

MOTIVATION : Domain adaptation allows for development of predictive models even in cases with limited sample data. Weighted elastic net domain adaptation specifically leverages features of genomic data to maximize transferability but the method is too computationally demanding to apply to many genome-sized datasets.

RESULTS : We developed wenda_gpu, which uses GPyTorch to train models on genomic data within hours on a single GPU-enabled machine. We show that wenda_gpu returns comparable results to the original wenda implementation, and that it can be used for improved prediction of cancer mutation status on small sample sizes than regular elastic net.

AVAILABILITY : wenda_gpu is available on GitHub at

SUPPLEMENTARY INFORMATION : Supplementary data are available at Bioinformatics online.

Hippen Ariel A, Crawford Jake, Gardner Jacob R, Greene Casey S