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Unraveling the mystery of efficacy in Chinese medicine formula: new approaches and technologies for research on pharmacodynamic substances.

In Arabian journal of chemistry

Traditional Chinese medicine (TCM) is the key to unlock treasures of Chinese civilization. TCM and its compound play a beneficial role in medical activities to cure diseases, especially in major public health events such as novel coronavirus epidemics across the globe. The chemical composition in Chinese medicine formula is complex and diverse, but their effective substances resemble "mystery boxes". Revealing their active ingredients and their mechanisms of action has become focal point and difficulty of research for herbalists. Although the existing research methods are numerous and constantly updated iteratively, there is remain a lack of prospective reviews. Hence, this paper provides a comprehensive account of existing new approaches and technologies based on previous studies with an in vitro to in vivo perspective. In addition, the bottlenecks of studies on Chinese medicine formula effective substances are also revealed. Especially, we look ahead to new perspectives, technologies and applications for its future development. This work reviews based on new perspectives to open horizons for the future research. Consequently, herbal compounding pharmaceutical substances study should carry on the essence of TCM while pursuing innovations in the field.

Li Yaolei, Lin Zhijian, Wang Yu, Ju Shanshan, Wu Hao, Jin Hongyu, Ma Shuangcheng, Zhang Bing

2022-Sep-27

2D, Two Dimensional, 3D, Three Dimensional, ADME, Absorption, Distribution, Metabolism, and Excretion, AFA DESI-MSI, Air flow-assisted desorption electrospray ionization mass spectrometry imaging, AI, Artificial Intelligence, Active ingredient, CDE, Center for Drug Evaluation, COX-2, Cyclooxygenase 2, Chemical components, Chinese medicine formula, Compound, Disease Targets, GC-MS, Gas chromatography-mass spectrometry, HPLC, High Performance Liquid Chromatography, HR-MS, High Resolution Mass Spectrometry, HTS, High Throughput Screening, HUA, hyperuricemia, ICPMS, inductively coupled plasma mass spectrometry, MALDI MS, Matrix for surface-assisted laser desorption/ionization mass spectrometry, MD, Microdialysis, MI, Molecular imprinting, MSI, Mass spectrometry imaging, Mass Spectrometry, NL/PR, Neutral loss/precursor ion, NMPA, National Medical Products Administration, OPLS-DA, Orthogonal partial least squares discriminant analysis, PD, Pharmacodynamic, PK, Pharmacokinetic, Q-TOF/MS, Quadrupole time-of-flight mass spectrometry, QSAR, Quantitative structure-activity relationship, QqQ-MS, Triple quadruple mass spectrometry, R-strategy, Reduce strategy, TCM, Traditional Chinese medicine, UF, Affinity ultrafiltration, UPLC, Ultra Performance Liquid Chromatography, XO, Xanthine oxidase