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In Computer methods and programs in biomedicine

OBJECTIVE : Pulmonary tuberculosis can promote pneumoconiosis deterioration, leading to higher mortality. This study aims to explore the diagnostic value of the cascading deep supervision U-Net (CSNet) model in pneumoconiosis complicated with pulmonary tuberculosis.

METHODS : A total of 162 patients with pneumoconiosis treated in our hospital were collected as the research objects. Patients were randomly divided into a training set (n = 113) and a test set (n = 49) in proportion (7:3). Based on the high-resolution computed tomography (HRCT), the traditional U-Net, supervision U-Net (SNet), and CSNet prediction models were constructed. Dice similarity coefficients, precision, recall, volumetric overlap error, and relative volume difference were used to evaluate the segmentation model. The area under the receiver operating characteristic curve (AUC) value represents the prediction efficiency of the model.

RESULTS : There were no statistically significant differences in gender, age, number of positive patients, and dust contact time between patients in the training set and test set (P > 0.05). The segmentation results of CSNet are better than the traditional U-Net model and the SNet model. The AUC value of the CSNet model was 0.947 (95% CI: 0.900∼0.994), which was higher than the traditional U-Net model.

CONCLUSION : The CSNet based on chest HRCT proposed in this study is superior to the traditional U-Net segmentation method in segmenting pneumoconiosis complicated with pulmonary tuberculosis. It has good prediction efficiency and can provide more clinical diagnostic value.

Hu Maoneng, Wang Zichen, Hu Xinxin, Wang Yi, Wang Guoliang, Ding Huanhuan, Bian Mingmin


Cascading deep supervision U-Net, Deep learning, High-resolution CT, Pneumoconiosis, Pulmonary tuberculosis