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Engineering multicellular living systems-A Keystone Symposia report.

In Annals of the New York Academy of Sciences

The ability to engineer complex multicellular systems has enormous potential to inform our understanding of biological processes and disease and alter the drug development process. Engineering living systems to emulate natural processes or to incorporate new functions relies on a detailed understanding of the biochemical, mechanical, and other cues between cells and between cells and their environment that result in the coordinated action of multicellular systems. On April 3-6, 2022, experts in the field met at the Keystone symposium "Engineering Multicellular Living Systems" to discuss recent advances in understanding how cells cooperate within a multicellular system, as well as recent efforts to engineer systems like organ-on-a-chip models, biological robots, and organoids. Given the similarities and common themes, this meeting was held in conjunction with the symposium "Organoids as Tools for Fundamental Discovery and Translation".

Cable Jennifer, Arlotta Paola, Parker Kevin Kit, Hughes Alex J, Goodwin Katharine, Mummery Christine L, Kamm Roger D, Engle Sandra J, Tagle Danilo A, Boj Sylvia F, Stanton Alice E, Morishita Yoshihiro, Kemp Melissa L, Norfleet Dennis A, May Elebeoba E, Lu Aric, Bashir Rashid, Feinberg Adam W, Hull Sarah M, Gonzalez Anjelica L, Blatchley Michael R, Montserrat Pulido Núria, Morizane Ryuji, McDevitt Todd C, Mishra Deepak, Mulero-Russe Adriana

2022-Sep-30

computational, engineered living, engineered organs, multicellular, systems