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In Expert review of respiratory medicine

OBJECTIVES : To identify early indicators for invasive mechanical ventilation utilization among COVID-19 patients.

METHODS : This retrospective study evaluated COVID-19 patients who were admitted to hospital from September 20, 2020, to August 8, 2021. Patients' clinical characteristics, demographics, comorbidities, and laboratory results were evaluated. Multivariable logistic regression and machine learning (ML) methods were employed to assess variable significance.

RESULTS : Among 1,613 confirmed COVID-19 patients, 365 patients (22.6%) received invasive mechanical ventilation (IMV). Factors associated with IMV included older age >65 years (OR,1.46; 95%CI, 1.13 - 1.89), current smoking status (OR, 1.71; 95%CI, 1.22-2.41), critical disease at admission (OR, 1.97; 95%CI, 1.28-3.03), and chronic kidney disease (OR, 2.07; 95%CI, 1.37-3.13). Laboratory abnormalities that were associated with increased risk for IMV included high leukocyte count (OR, 2.19; 95%CI, 1.68 - 2.87), low albumin (OR, 1.76; 95%CI, 1.33 - 2.34) and high AST (OR, 1.71; 95%CI, 1.31 - 2.22).

CONCLUSION : Our study suggests that there are several factors associated with the increased need for IMV among COVID-19 patients including older age, current smoking status, critical disease status on admission, and chronic kidney disease. In addition, laboratory markers such as high leukocyte count, low albumin and high AST were determined. These findings will help in early identification of patients at high risk for IMV and reallocation of hospital resources towards patients who need them the most to improve their outcomes.

Kabbaha Suad, Al-Azzam Sayer, Karasneh Reema A, Khassawneh Basheer Y, Al-Mistarehi Abdel-Hameed, Lattyak William J, Aldiab Motasem, Hasan Syed Shahzad, Conway Barbara R, Aldeyab Mamoon A


COVID-19, Comorbidity, Invasive Mechanical Ventilation, Laboratory, Predictor, Risk Factor, SARS‐CoV‐2, Severity