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In Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

OBJECTIVE : Childhood absence epilepsy (CAE) is a disease with distinct seizure semiology and electroencephalographic (EEG) features. Differentiating ictal and subclinical generalized spikes and waves discharges (GSWDs) in the EEG is challenging, since they appear to be identical upon visual inspection. Here, spectral and functional connectivity (FC) analyses were applied to routine EEG data of CAE patients, to differentiate ictal and subclinical GSWDs.

METHODS : Twelve CAE patients with both ictal and subclinical GSWDs were retrospectively selected for this study. The selected EEG epochs were subjected to frequency analysis in the range of 1-30 Hz. Further, FC analysis based on the imaginary part of coherency was used to determine sensor level networks.

RESULTS : Delta, alpha and beta band frequencies during ictal GSWDs showed significantly higher power compared to subclinical GSWDs. FC showed significant network differences for all frequency bands, demonstrating weaker connectivity between channels during ictal GSWDs.

CONCLUSION : Using spectral and FC analyses significant differences between ictal and subclinical GSWDs in CAE patients were detected, suggesting that these features could be used for machine learning classification purposes to improve EEG monitoring.

SIGNIFICANCE : Identifying differences between ictal and subclinical GSWDs using routine EEG, may improve understanding of this syndrome and the management of patients with CAE.

Kumar Ami, Lyzhko Ekaterina, Hamid Laith, Srivastav Anand, Stephani Ulrich, Japaridze Natia

2021-Jul-01

Childhood Absence Epilepsy, EEG, Functional Connectivity, Spectral analysis, ictal GSWDs, subclinical GSWDs