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In IEEE/ACM transactions on computational biology and bioinformatics

Previous studies have either learned drugs features from their string or numeric representations, which are not natural forms of drugs, or only used genomic data of cell lines for the drug response prediction problem. Here, we proposed a deep learning model, GraOmicDRP, to learn drugs features from their graph representation and integrate multiple -omic data of cell lines. In GraOmicDRP, drugs are represented as graphs of bindings among atoms; meanwhile, cell lines are depicted by not only genomic but also transcriptomic and epigenomic data. Graph convolutional and convolutional neural networks were used to learn the representation of drugs and cell lines, respectively. A combination of the two representations was then used to be representative of each pair of drug-cell line. Finally, the response value of each pair was predicted by a fully connected network. Experimental results indicate that transcriptomic data shows the best among single -omic data; meanwhile, the combinations of transcriptomic and other omic data achieved the best performance overall in terms of both Root Mean Square Error and Pearson correlation coefficient. In addition, we also show that GraOmicDRP outperforms some state-of-the-art methods, including ones integrating omic data with drug information such as GraphDRP, and ones using omic data without drug information such as DeepDR and MOLI.

Nguyen Giang Thi Thu, Vu Duc-Hoa, Le Duc-Hau

2021-Jul-14