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In Journal of natural products ; h5-index 43.0

The tropolone-bearing sesquiterpenes juniperone A (1) and norjuniperone A (2) were isolated from the folk medicinal plant Juniperus chinensis, and their structures were determined by a combination of spectroscopic and crystallographic methods. Photojuniperones A1 (3) and A2 (4), bearing bicyclo[3,2,0]heptadienones derived from tropolone, were photochemically produced and structurally identified by spectroscopic methods. Predicted by the machine learning-based assay, 1 significantly inhibited the action of tyrosinase. The new compounds also inhibited lipid accumulation and enhanced the extracellular glycerol excretion.

Park Jae Sung, Ko Keebeom, Kim Seong-Hwan, Lee Jae Kyun, Park Jin-Soo, Park Keunwan, Kim Mi Ri, Kang Kyungsu, Oh Dong-Chan, Kim Sun Yeou, Yumnam Silvia, Kwon Hak Cheol, Shin Jongheon

2021-Jul-08