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In Methods in molecular biology (Clifton, N.J.)

Protein subcellular localization prediction (PSLP), which plays an important role in the field of computational biology, identifies the position and function of proteins in cells without expensive cost and laborious effort. In the past few decades, various methods with different algorithms have been proposed in solving the problem of subcellular localization prediction; machine learning and deep learning constitute a large portion among those proposed methods. In order to provide an overview about those methods, the first part of this article will be a brief review of several state-of-the-art machine learning methods on subcellular localization prediction; then the materials used by subcellular localization prediction is described and a simple prediction method, that takes protein sequences as input and utilizes a convolutional neural network as the classifier, is introduced. At last, a list of notes is provided to indicate the major problems that may occur with this method.

Pan Gaofeng, Sun Chao, Liao Zijun, Tang Jijun


Deep learning, Evolution information, Feature extraction, Machine learning, Multi-label classification, Protein sequence, Protein subcellular localization prediction