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In The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

INTRODUCTION : Placenta accreta spectrum is a major obstetric disorder that is associated with significant morbidity and mortality. The objective of this study is to establish a prediction model of clinical outcomes in these women.

MATERIALS AND METHODS : PAS-ID is an international multicenter study that comprises 11 centers from 9 countries. Women who were diagnosed with PAS and were managed in the recruiting centers between 1 January 2010 and 31 December 2019 were included. Data were reanalyzed using machine learning (ML) models, and 2 models were created to predict outcomes using antepartum and perioperative features. ML model was conducted using python® programing language. The primary outcome was massive PAS-associated perioperative blood loss (intraoperative blood loss ≥2500 ml, triggering massive transfusion protocol, or complicated by disseminated intravascular coagulopathy). Other outcomes include prolonged hospitalization >7 days and admission to the intensive care unit (ICU).

RESULTS : 727 women with PAS were included. The area under curve (AUC) for ML antepartum prediction model was 0.84, 0.81, and 0.82 for massive blood loss, prolonged hospitalization, and admission to ICU, respectively. Significant contributors to this model were parity, placental site, method of diagnosis, and antepartum hemoglobin. Combining baseline and perioperative variables, the ML model performed at 0.86, 0.90, and 0.86 for study outcomes, respectively. Ethnicity, pelvic invasion, and uterine incision were the most predictive factors in this model.

DISCUSSION : ML models can be used to calculate the individualized risk of morbidity in women with PAS. Model-based risk assessment facilitates a priori delineation of management.

Shazly Sherif A, Hortu Ismet, Shih Jin-Chung, Melekoglu Rauf, Fan Shangrong, Ahmed Farhat Ul Ain, Karaman Erbil, Fatkullin Ildar, Pinto Pedro V, Irianti Setyorini, Tochie Joel Noutakdie, Abdelbadie Amr S, Ergenoglu Ahmet M, Yeniel Ahmet O, Sagol Sermet, Itil Ismail M, Kang Jessica, Huang Kuan-Ying, Yilmaz Ercan, Liang Yiheng, Aziz Hijab, Akhter Tayyiba, Ambreen Afshan, Ateş Çağrı, Karaman Yasemin, Khasanov Albir, Larisa Fatkullina, Akhmadeev Nariman, Vatanina Adelina, Machado Ana Paula, Montenegro Nuno, Effendi Jusuf S, Suardi Dodi, Pramatirta Ahmad Y, Aziz Muhamad A, Siddiq Amilia, Ofakem Ingrid, Dohbit Julius Sama, Fahmy Mohamed S, Anan Mohamed A


Obstetric hemorrhage, cesarean hysterectomy, machine learning, morbidly adherent placenta, placenta accreta spectrum, placenta praevia