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In Computers in biology and medicine

This paper investigates the feasibility of using non-cerebral, time-series data to detect epileptic seizures. Data were recorded from fifteen patients (7 male, 5 female, 3 not noted, mean age 36.17 yrs), five of whom had a total of seven seizures. Patients were monitored in an inpatient setting using standard video-electroencephalography (vEEG), while also wearing sensors monitoring electrocardiography, electrodermal activity, electromyography, accelerometry, and audio signals (vocalizations). A systematic and detailed study was conducted to identify the sensors and the features derived from the non-cerebral sensors that contribute most significantly to separability of data acquired during seizures from non-seizure data. Post-processing of the data using linear discriminant analysis (LDA) shows that seizure data are strongly separable from non-seizure data based on features derived from the signals recorded. The mean area under the receiver operator characteristic (ROC) curve for each individual patient that experienced a seizure during data collection, calculated using LDA, was 0.9682. The features that contribute most significantly to seizure detection differ for each patient. The results show that a multimodal approach to seizure detection using the specified sensor suite is promising in detecting seizures with both sensitivity and specificity. Moreover, the study provides a means to quantify the contribution of each sensor and feature to separability. Development of a non-electroencephalography (EEG) based seizure detection device would give doctors a more accurate seizure count outside of the clinical setting, improving treatment and the quality of life of epilepsy patients.

Hamlin Alexandra, Kobylarz Erik, Lever James H, Taylor Susan, Ray Laura

2021-Jan-21

Biomedical computing, Biomedical signal processing, Decision-support systems, Machine learning, Wearable sensors