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In Frontiers in cell and developmental biology

Brain functional networks constructed via regularization has been widely used in early mild cognitive impairment (eMCI) classification. However, few methods can properly reflect the similarities and differences of functional connections among different people. Most methods ignore some topological attributes, such as connection strength, which may delete strong functional connections in brain functional networks. To overcome these limitations, we propose a novel method to construct dynamic functional networks (DFN) based on weighted regularization (WR) and tensor low-rank approximation (TLA), and apply it to identify eMCI subjects from normal subjects. First, we introduce the WR term into the DFN construction and obtain WR-based DFNs (WRDFN). Then, we combine the WRDFNs of all subjects into a third-order tensor for TLA processing, and obtain the DFN based on WR and TLA (WRTDFN) of each subject in the tensor. We calculate the weighted-graph local clustering coefficient of each region in each WRTDFN as the effective feature, and use the t-test for feature selection. Finally, we train a linear support vector machine (SVM) classifier to classify the WRTDFNs of all subjects. Experimental results demonstrate that the proposed method can obtain DFNs with the scale-free property, and that the classification accuracy (ACC), the sensitivity (SEN), the specificity (SPE), and the area under curve (AUC) reach 87.0662% ± 0.3202%, 83.4363% ± 0.5076%, 90.6961% ± 0.3250% and 0.9431 ± 0.0023, respectively. We also achieve the best classification results compared with other comparable methods. This work can effectively improve the classification performance of DFNs constructed by existing methods for eMCI and has certain reference value for the early diagnosis of Alzheimer's disease (AD).

Jiao Zhuqing, Ji Yixin, Zhang Jiahao, Shi Haifeng, Wang Chuang


classification, dynamic functional network (DFN), early mild cognitive impairment (eMCI), tensor low-rank approximation (TLA), weighted regularization (WR)