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In Translational vision science & technology

Purpose : The purpose of this study was to evaluate the diagnostic performance of deep learning (DL) anterior segment optical coherence tomography (AS-OCT) as a plateau iris prediction model.

Design : We used a cross-sectional study of the development and validation of the DL system.

Methods : We conducted a collaboration between a referral eye center and an informative technology department. The study enrolled 179 eyes from 142 patients with primary angle closure disease (PACD). All patients had remaining appositional angle after iridotomy. Each eye was scanned in four quadrants for both AS-OCT and ultrasound biomicroscopy (UBM). A DL algorithm for plateau iris prediction of AS-OCT was developed from training datasets and was validated in test sets. Sensitivity, specificity, and area under the receiver operating characteristics curve (AUC-ROC) of the DL for predicting plateau iris were evaluated, using UBM as a reference standard.

Results : Total paired images of AS-OCT and UBM were from 716 quadrants. Plateau iris was observed with UBM in 276 (38.5%) quadrants. Trainings dataset with data augmentation were used to develop an algorithm from 2500 images, and the test set was validated from 160 images. AUC-ROC was 0.95 (95% confidence interval [CI] = 0.91 to 0.99), sensitivity was 87.9%, and specificity was 97.6%.

Conclusions : DL revealed a high performance in predicting plateau iris on the noncontact AS-OCT images.

Translational Relevance : This work could potentially assist clinicians in more practically detecting this nonpupillary block mechanism of PACD.

Wanichwecharungruang Boonsong, Kaothanthong Natsuda, Pattanapongpaiboon Warisara, Chantangphol Pantid, Seresirikachorn Kasem, Srisuwanporn Chaniya, Parivisutt Nucharee, Grzybowski Andrzej, Theeramunkong Thanaruk, Ruamviboonsuk Paisan

2021-Jan

Asian, accuracy, anterior segment optical coherence tomography (AS-OCT), artificial intelligence, deep learning (DL), diagnostic performance, ocular imaging, plateau iris, primary angle-closure glaucoma, sensitivity, specificity, style transfer, ultrasound biomicroscopy