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In Giornale italiano di cardiologia (2006)

Heart failure (HF) is a syndrome with an uncertain definition for both contents and boundaries, with multiple components and clinical profiles, and treatments to which many HF patients do not respond.This article does not go through the guidelines, but it focuses on some clinically relevant points, in which research is active, to discuss them and, when possible, to make the point under a clinical cardiology vision.Aspects considered include: (i) the concept of "definition"; (ii) HF with preserved or reduced ejection fraction; (iii) sudden death; (iv) briefly: population genetics, polygenic risk scores and the OMICs; (v) atrial fibrillation ablation in HF (underlying inconsistency of international guidelines); (vi) the welcome rampant/crawling penetration of artificial intelligence in daily HF management.

Tavazzi Luigi