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In Journal of clinical medicine

Lung cancer is still the leading cause of cancer death in the world. For this reason, novel approaches for early and more accurate diagnosis are needed. Computer-aided decision (CAD) can be an interesting option for a noninvasive tumour characterisation based on thoracic computed tomography (CT) image analysis. Until now, radiomics have been focused on tumour features analysis, and have not considered the information on other lung structures that can have relevant features for tumour genotype classification, especially for epidermal growth factor receptor (EGFR), which is the mutation with the most successful targeted therapies. With this perspective paper, we aim to explore a comprehensive analysis of the need to combine the information from tumours with other lung structures for the next generation of CADs, which could create a high impact on targeted therapies and personalised medicine. The forthcoming artificial intelligence (AI)-based approaches for lung cancer assessment should be able to make a holistic analysis, capturing information from pathological processes involved in cancer development. The powerful and interpretable AI models allow us to identify novel biomarkers of cancer development, contributing to new insights about the pathological processes, and making a more accurate diagnosis to help in the treatment plan selection.

Pereira Tania, Freitas Cláudia, Costa José Luis, Morgado Joana, Silva Francisco, Negrão Eduardo, de Lima Beatriz Flor, da Silva Miguel Correia, Madureira António J, Ramos Isabel, Hespanhol Venceslau, Cunha António, Oliveira Hélder P


computed tomography analysis, computer-aided decision, lung cancer assessment, personalised medicine, tumour characterisation