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In Journal of gastroenterology and hepatology ; h5-index 51.0

BACKGROUND AND AIM : Previous 2 generations of esophageal capsule did not show adequate detection rates for Barrett's esophagus (BE). We assessed the diagnostic accuracy of a novel third generation capsule with an improved frame rate of 35 frames per second for the detection of BE in a pilot study.

METHODS : This was a blinded prospective pilot study conducted at a tertiary medical center. Patients with known BE (at least C0M>1) who presented for endoscopic surveillance (May to October 2017) were included. All patients underwent novel esophageal capsule (PillCamTM UGI; Medtronic) ingestion using the simplified ingestion protocol followed by standard high definition upper endoscopy (EGD). Capsule endoscopy findings were interpreted by examiners blinded to endoscopy results and compared to endoscopic findings (gold standard). Following completion of both tests, a subjective questionnaire was provided to all patients regarding their experience.

RESULTS : Twenty patients [95%males, mean age 66.3 (+/-7.9)years] with BE undergoing surveillance EGD were eligible. The mean BE length was 3.5 (+/-2.7)cm. Novel esophageal capsule detected BE in 75% patients when images were compared to endoscopy. Novel capsule detected BE in 82% patients when the BE length was >=2cm. The mean esophageal transit time was 0.59 sec. On a subjective questionnaire, all 20 patients reported novel capsule as being more convenient compared to EGD.

CONCLUSIONS : In this pilot, single center study, novel esophageal capsule was shown to be not ready for population screening of BE. Studies integrating artificial intelligence into improved quality novel esophageal capsule should be performed for BE screening.

Duvvuri Abhiram, Desai Madhav, Vennelaganti Sreekar, Higbee April, Gorrepati Venkat Subhash, Dasari Chandra, Chandrasekar Viveksandeep Thoguluva, Vennalaganti Prashanth, Kohli Divyanshoo, Sathyamurthy Anjana, Rai Tarun, Sharma Prateek