Deep learning in in-vitro fertilization is currently being evaluated in the development of assistive tools for the determination of transfer order and implantation potential using time-lapse data collected through expensive imaging hardware. Assistive tools and algorithms that can work with static images, however, can help in improving the access to care by enabling their use with images acquired from traditional microscopes that are available to virtually all fertility centers. Here, we evaluated the use of a deep convolutional neural network (CNN), trained using single timepoint images of embryos collected at 113 hours post-insemination, in embryo selection amongst 97 clinical patient cohorts (742 embryos) and observed an accuracy of 90% in choosing the highest quality embryo available. Furthermore, a CNN trained to assess an embryo's implantation potential directly using a set of 97 euploid embryos capable of implantation outperformed 15 trained embryologists (75.26% vs. 67.35%, P<0.0001) from 5 different fertility centers.
Bormann Charles L, Kanakasabapathy Manoj Kumar, Thirumalaraju Prudhvi, Gupta Raghav, Pooniwala Rohan, Kandula Hemanth, Hariton Eduardo, Souter Irene, Dimitriadis Irene, Ramirez Leslie B, Curchoe Carol L, Swain Jason E, Boehnlein Lynn M, Shafiee Hadi